Sep 21, 2017
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Top 20 Most Popular Drugs

We've provided a list of the most popular/processed drugs in the U.S. We also provided free prescription savings coupons that offer great discounts on these drugs. Check out our list of the 20 most popular drugs below. Don't forget to visit our Medication Pricing Tool to see how much you can save on these prescription medications!

1 Hydrocodone APAP

Category: Pain Relief

Hydrocodone relieves pain by changing the way the brain and nervous system respond to pain. Hydrocodone is in a class of medications called opiate (narcotic) analgesics and in a class of medications called antitussives.

2 Phentermine

Category: Weight Loss & Diet

Phentermine is used for a limited period of time to speed weight loss in overweight people who are exercising and eating a low-calorie diet. Phentermine is in a class of medications called anorectics. It works by decreasing appetite.

3 Tramadol HCL

Category: Pain Relief

Tramadol is used to relieve moderate to moderately severe pain. Tramadol extended-release tablets and capsules are only used by people who are expected to need medication to relieve pain around-the-clock . Tramadol is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

4 Vitamin D

Vitamin D is a nutrient found in some foods that is needed for health and to maintain strong bones. It does so by helping the body absorb calcium (one of bone's main building blocks) from food and supplements.

5 Zolpidem

Category: Sleep Help

Zolpidem is used to treat insomnia (difficulty falling asleep or staying asleep). Zolpidem belongs to a class of medications called sedative-hypnotics. It works by slowing activity in the brain to allow sleep.

6 Amoxicillin

Category: Antibiotics

Amoxicillin is used to treat certain infections caused by bacteria. It is also used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers. Amoxicillin is in a class of medications called penicillin-like antibiotics. It works by stopping the growth of bacteria. Antibiotics will not work for colds, flu, and other viral infections.

7 Cyclobenzaprine

Category: Pain Relief

Cyclobenzaprine, a muscle relaxant, is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries.

8 Ferrous Sulfate

Ferrous sulfate provides the iron needed by the body to produce red blood cells. It is used to treat or prevent iron-deficiency anemia, a condition that occurs when the body has too few red blood cells because of pregnancy, poor diet, excess bleeding, or other medical problems.

9 Hydrochlorothiazide

Hydrochlorothiazide is used alone or in combination with other medications to treat high blood pressure. Hydrochlorothiazide is used to treat edema caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Hydrochlorothiazide is in a class of medications called diuretics ('water pills').

10 Alprazolam

Category: Anxiety

Alprazolam is used to treat anxiety disorders and panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks). Alprazolam is in a class of medications called benzodiazepines. It works by decreasing abnormal excitement in the brain.

11 Lisinopril

Lisinopril is used alone or in combination with other medications to treat high blood pressure. It is used in combination with other medications to treat heart failure. Lisinopril is also used to improve survival after a heart attack. Lisinopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors.

12 Folic Acid

Folic acid is a B vitamin. It helps the body make healthy new cells. Everyone needs folic acid. For women who may get pregnant, it is really important. Getting enough folic acid before and during pregnancy can prevent major birth defects of her baby's brain or spine.

13 Amlodipine

Amlodipine is used alone or in combination with other medications to treat high blood pressure and chest pain (angina). Amlodipine is in a class of medications called calcium channel blockers. It lowers blood pressure by relaxing the blood vessels so the heart does not have to pump as hard. It controls chest pain by increasing the supply of blood to the heart.

14 Suboxone

Category: Substance Withdrawal

Buprenorphine (Subutex) and buprenorphine and naloxone (Suboxone) are used to treat opioid dependence (addiction to opioid drugs, including heroin and narcotic painkillers). Buprenorphine is in a class of medications called opioid partial agonist-antagonists, and naloxone is in a class of medications called opioid antagonists.

15 Loratadine

Category: Flu & Allergy

Loratadine is used to temporarily relieve the symptoms of hay fever and other allergies. These symptoms include sneezing, runny nose, and itchy eyes, nose, or throat. Loratadine is also used to treat itching and redness caused by hives. However, loratadine does not prevent hives or other allergic skin reactions. Loratadine is in a class of medications called antihistamines.

16 Oxycodone/APAP

Category: Pain Relief

Oxycodone is used to relieve moderate to severe pain. Oxycodone extended-release tablets are used to relieve severe pain in people who are expected to need pain medication around the clock for a long time and who cannot be treated with other medications. Oxycodone is in a class of medications called opiate (narcotic) analgesics.

17 Azithromycin

Category: Antibiotics

Azithromycin is used to treat certain bacterial infections, such as bronchitis; pneumonia; sexually transmitted diseases (STD); and infections of the ears, lungs, sinuses, skin, throat, and reproductive organs. Azithromycin also is used to treat or prevent disseminated Mycobacterium avium complex (MAC) infection. Azithromycin is in a class of medications called macrolide antibiotics.

18 Cephalexin

Category: Antibiotics

Cephalexin is a cephalosporin antibiotic used to treat certain infections caused by bacteria such as pneumonia and bone, ear, skin, and urinary tract infections. Antibiotics will not work for colds, flu, or other viral infections.

18 Amphetamine Salts

Category: ADHD

Amphetamine is used to treat attention-deficit hyperactivity disorder (ADHD). It may also be used for narcolepsy. ADHD agents are most often stimulants that increase alertness, wakefulness, focus and concentration.

19 SMZ/TMP DS

Category: Antibiotics

Sulfamethoxazole and trimethoprim are both antibiotics that treat different types of infection caused by bacteria. Sulfamethoxazole and trimethoprim is used a combination antibiotic used to treat ear infections, urinary tract infections, bronchitis, traveler's diarrhea, shigellosis, and Pneumocystis jiroveci pneumonia.

20 Carisoprodol

Category: Pain Relief

Carisoprodol, a muscle relaxant, is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries.

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